Stimulation of transient versus sustained ERK1/2 phosphorylation by relative chitinase-like proteins CHI3L1 and CHI3L2 correlates with different kinase localization and biological outcome

• Дата: 2011
• Автори: Areshkov, P.O., Avdieiev, S.S., Iershov, A.V., Kavsan, V.M.
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут молекулярної біології і генетики НАН України 2011
• Назва видання: Вiopolymers and Cell
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/155649
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Stimulation of transient versus sustained ERK1/2 phosphorylation by relative chitinase-like proteins CHI3L1 and CHI3L2 correlates with different kinase localization and biological outcome / P.O. Areshkov, S.S. Avdieiev, A.V. Iershov, V.M. Kavsan // Вiopolymers and Cell. — 2011. — Т. 27, № 5. — С. 343-346. — Бібліогр.: 12 назв. — англ.

Aim. To determine 293 and U373 cell response and ERK1/2 activation profile after CHI3L1 or CHI3L2 treatment. Methods. Specific activation and localization of ERK1/2 kinases after CHI3L1 or CHI3L2 addition to unsupplemented cell medium were evaluated by Western blots, immunofluorescence and confocal...