Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient
Progressive multifocal leukoencephalopathy (PML) is a neurological disease caused by infection of the central nervous system (CNS) with the JC polyomavirus (JCV). JCV is endemic and infects a large proportion (70–90%) of healthy individuals worldwide, but infection is latent. JCV reactivation may oc...
Збережено в:
| Опубліковано в: : | Experimental Oncology |
|---|---|
| Дата: | 2011 |
| Автори: | , , , , , , , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2011
|
| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/138666 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient / S. Lejniece, M. Murovska, S. Chapenko, B. Breiksa, Z. Jaunmuktane, L. Feldmane, I. Ziedlina, J. Gomez-Roman, M. Garcia-Cabeza, A. Lejnieks // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 239-241. — Бібліогр.: 13 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
nasplib_isofts_kiev_ua-123456789-138666 |
|---|---|
| record_format |
dspace |
| spelling |
Lejniece, S. Murovska, M. Chapenko, S. Breiksa, B. Jaunmuktane, Z. Feldmane, L. Ziedlina, I. Gomez-Roman, J. Garcia-Cabeza, M. Lejnieks, A. 2018-06-19T11:19:10Z 2018-06-19T11:19:10Z 2011 Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient / S. Lejniece, M. Murovska, S. Chapenko, B. Breiksa, Z. Jaunmuktane, L. Feldmane, I. Ziedlina, J. Gomez-Roman, M. Garcia-Cabeza, A. Lejnieks // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 239-241. — Бібліогр.: 13 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/138666 Progressive multifocal leukoencephalopathy (PML) is a neurological disease caused by infection of the central nervous system (CNS) with the JC polyomavirus (JCV). JCV is endemic and infects a large proportion (70–90%) of healthy individuals worldwide, but infection is latent. JCV reactivation may occur, if the immune function is compromised. Aim: To present a PML case in a CLL patient after a long course of disease and treatment with fludarabine. JCV virus infection in this patient was proven both in brain biopsy material and blood. Methods: Patient with a nine-year history of CLL was hospitalized with the weakness in the right leg and left hand, tremors, speech difficulties. An MRI diagnosed infiltrative glial tumor of the left hemisphere, proliferating predominantly in the frontal lobe, more in the gyrus frontalis superior region. CNS tumor biopsy performed. Results: Morphology and immunoprofile of the lesion consistent with progressive multifocal leukoencephalopathy. The material from biopsy was diagnosed as positive for JCV DNA. JCV and HHV-7 genomic sequences were found in patient’s PBL DNA sample. In a plasma DNA sample, only genomic sequences were detected. Conclusion: The present case draws attention to the fact that the use of fludarabine and its combinations in CLL therapy increases the risk of JCV infection reactivation and development of serious complications like PML. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| spellingShingle |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient Lejniece, S. Murovska, M. Chapenko, S. Breiksa, B. Jaunmuktane, Z. Feldmane, L. Ziedlina, I. Gomez-Roman, J. Garcia-Cabeza, M. Lejnieks, A. Short communications |
| title_short |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| title_full |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| title_fullStr |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| title_full_unstemmed |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| title_sort |
progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient |
| author |
Lejniece, S. Murovska, M. Chapenko, S. Breiksa, B. Jaunmuktane, Z. Feldmane, L. Ziedlina, I. Gomez-Roman, J. Garcia-Cabeza, M. Lejnieks, A. |
| author_facet |
Lejniece, S. Murovska, M. Chapenko, S. Breiksa, B. Jaunmuktane, Z. Feldmane, L. Ziedlina, I. Gomez-Roman, J. Garcia-Cabeza, M. Lejnieks, A. |
| topic |
Short communications |
| topic_facet |
Short communications |
| publishDate |
2011 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Progressive multifocal leukoencephalopathy (PML) is a neurological disease caused by infection of the central nervous system (CNS) with the JC polyomavirus (JCV). JCV is endemic and infects a large proportion (70–90%) of healthy individuals worldwide, but infection is latent. JCV reactivation may occur, if the immune function is compromised. Aim: To present a PML case in a CLL patient after a long course of disease and treatment with fludarabine. JCV virus infection in this patient was proven both in brain biopsy material and blood. Methods: Patient with a nine-year history of CLL was hospitalized with the weakness in the right leg and left hand, tremors, speech difficulties. An MRI diagnosed infiltrative glial tumor of the left hemisphere, proliferating predominantly in the frontal lobe, more in the gyrus frontalis superior region. CNS tumor biopsy performed. Results: Morphology and immunoprofile of the lesion consistent with progressive multifocal leukoencephalopathy. The material from biopsy was diagnosed as positive for JCV DNA. JCV and HHV-7 genomic sequences were found in patient’s PBL DNA sample. In a plasma DNA sample, only genomic sequences were detected. Conclusion: The present case draws attention to the fact that the use of fludarabine and its combinations in CLL therapy increases the risk of JCV infection reactivation and development of serious complications like PML.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/138666 |
| citation_txt |
Progressive multifocal leukoencephalopathy following fludarabine treatment in a chronic lymphocytic leukemia patient / S. Lejniece, M. Murovska, S. Chapenko, B. Breiksa, Z. Jaunmuktane, L. Feldmane, I. Ziedlina, J. Gomez-Roman, M. Garcia-Cabeza, A. Lejnieks // Experimental Oncology. — 2011. — Т. 33, № 4. — С. 239-241. — Бібліогр.: 13 назв. — англ. |
| work_keys_str_mv |
AT lejnieces progressivemultifocalleukoencephalopathyfollowingfludarabinetreatmentinachroniclymphocyticleukemiapatient AT murovskam progressivemultifocalleukoencephalopathyfollowingfludarabinetreatmentinachroniclymphocyticleukemiapatient AT chapenkos progressivemultifocalleukoencephalopathyfollowingfludarabinetreatmentinachroniclymphocyticleukemiapatient AT breiksab progressivemultifocalleukoencephalopathyfollowingfludarabinetreatmentinachroniclymphocyticleukemiapatient AT jaunmuktanez progressivemultifocalleukoencephalopathyfollowingfludarabinetreatmentinachroniclymphocyticleukemiapatient AT feldmanel progressivemultifocalleukoencephalopathyfollowingfludarabinetreatmentinachroniclymphocyticleukemiapatient AT ziedlinai progressivemultifocalleukoencephalopathyfollowingfludarabinetreatmentinachroniclymphocyticleukemiapatient AT gomezromanj progressivemultifocalleukoencephalopathyfollowingfludarabinetreatmentinachroniclymphocyticleukemiapatient AT garciacabezam progressivemultifocalleukoencephalopathyfollowingfludarabinetreatmentinachroniclymphocyticleukemiapatient AT lejnieksa progressivemultifocalleukoencephalopathyfollowingfludarabinetreatmentinachroniclymphocyticleukemiapatient |
| first_indexed |
2025-12-07T19:53:05Z |
| last_indexed |
2025-12-07T19:53:05Z |
| _version_ |
1850880489911484416 |