17-AAG mediates targeting of HSP90 limits tert activity in peritoneal sarcoma related malignant ascites by downregulating cyclin D1 during cell cycle entry

• Published in: Experimental Oncology
• Date: 2012
• Main Authors: Chaklader, M., Das, P., Pereira, J.A., Law, A., Chattopadhyay, S., Chatterjee, R., Mondal, A., Law, S.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/138688
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: 17-AAG mediates targeting of HSP90 limits tert activity in peritoneal sarcoma related malignant ascites by downregulating cyclin D1 during cell cycle entry / M. Chaklader, P. Das, J.A. Pereira, A. Law, S. Chattopadhyay, R. Chatterjee, A. Mondal, S. Law // Experimental Oncology. — 2012. — Т. 34, № 2. — С. 90-96. — Бібліогр.: 24 назв. — англ.

Aim: Peritoneal or retro-peritoneal sarcomatosis related malignant ascites formation is a rare but serious consequence of the locoregional metastatic event. The present work aimed to study the effect of the Hsp90 inhibitor (17-AAG), an ansamycin analog, on cell cycle and DNA replication specific cha...