Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate

• Veröffentlicht in: Experimental Oncology
• Datum: 2012
• Hauptverfasser: Vasilyeva, E.D., Kaledin, V., Nikolin, V.P., Popova, N.A., Kirilyuk, I.A., Grigor`ev, I.A.
• Format: Artikel
• Sprache: English
• Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
• Schlagworte: Short communications
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/138692
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate / E.D. Vasilyeva, V. Kaledin, V.P. Nicolin, N.A. Popova, I.A. Kirilyuk, I.A. Grigor`ev // Experimental Oncology. — 2012. — Т. 34, № 1. — С. 66-68. — Бібліогр.: 14 назв. — англ.

Aim: A recently discovered enzyme, indoleamine 2,3-dioxygenase (IDO), is expressed in placenta, dendritic cells and also in many kinds of tumors and in tumor-infiltrating macrophages. By catabolizing tryptophan, IDO causes local depletion of this essential amino acid and excess of kinurenin, and sup...