Accelerated cellular senescence in solid tumor therapy

• Published in: Experimental Oncology
• Date: 2012
• Main Authors: Wu, P.C., Wang, Q., Grobman, L., Chu, E., Wu, D.Y.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2012
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/139056
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Accelerated cellular senescence in solid tumor therapy / P.C. Wu, Q. Wang, L. Grobman, E. Chu, D.Y. Wu // Experimental Oncology. — 2012. — Т. 34, № 3. — С. 298-305. — Бібліогр.: 85 назв. — англ.

Accelerated cellular senescence (ACS) is an emerging concept that implicates sustained, telomere-independent cell cycle arrest of neoplastic cells in response to chemotherapeutic agents, ionizing radiation, oxidative stress, or the presence of selective oncogenic stimuli. Recent evidence suggests th...