Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients

• Published in: Experimental Oncology
• Date: 2018
• Main Authors: Abramenko, I.V., Bilous, N.I., Chumak, A.A., Dyagil, I.S., Martina, Z.V.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2018
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145636
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients / I.V. Abramenko, N.I. Bilous, A.A. Chumak, I.S. Dyagil, Z.V. Martina // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 211-217. — Бібліогр.: 31 назв. — англ.

Deregulation of NOTCH1-signalling pathway is common in chronic lymphocytic leukemia (CLL). The most of studies are focused on detection of the hotspot c.7541_7542delCT NOTCH1 mutations in exon 34, while studies of mutations in the 3′UTR region are rare. The aims of work were to evaluate the frequenc...