Effects of L-Arginine on Seizure Behavior and Expression of GFAP in Kainic Acid-Treated Rats

• Published in: Нейрофизиология
• Date: 2013
• Main Authors: Sun, Yi., Yin, Sh., Li, Sh., Yu, D., Gong, D., Xu, J., Lian, Yo, Sun, Ch
• Format: Article
• Language: English
• Published: Інститут фізіології ім. О.О. Богомольця НАН України 2013
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/148024
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Effects of L-Arginine on Seizure Behavior and Expression of GFAP in Kainic Acid-Treated Rats / Yi. Sun, Sh. Yin, Sh. Li, D. Yu, D. Gong, J. Xu, Yo. Lian, Ch. Sun // Нейрофизиология. — 2013. — Т. 45, № 1. — С. 25-30. — Бібліогр.: 28 назв. — англ.

Rats i.p. injected once with 10 mg/kg kainic acid exhibited clear seizure behavior (“wet-dog shakes,” rearing on the hindlimbs, and bilateral clonus). Pretreatment with L-arginine (L-Arg twice a day for 5 days) significantly decreased these manifestations. The medium dose of L-Arg (40 mg/kg) was...