Mitochondria do not play a major role in landomycin E-induced ROS burst and circumvention of multiple drug resistance in HL-60 leukemia cells

• Date: 2016
• Main Authors: Panchuk, R.R., Lehka, L.V., Rohr, J., Berger, W., Stoika, R.S.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2016
• Series: Вiopolymers and Cell
• Subjects: Genomics, Transcriptomics and Proteomics
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152824
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Mitochondria do not play a major role in landomycin E-induced ROS burst and circumvention of multiple drug resistance in HL-60 leukemia cells / R.R. Panchuk, L.V. Lehka, J. Rohr, W. Berger, R.S. Stoika // Вiopolymers and Cell. — 2016. — Т. 32, № 3. — С. 190-202. — Бібліогр.: 25 назв. — англ.

Aim. To study the molecular mechanisms of reactive oxygen species (ROS) involvement in circumventing the cancer drug resistance by novel angucycline antibiotic landomycin E in HL-60 human leukemia cells and its drug-resistant sublines HL-60/adr and HL-60/vinc. Methods. MTT assay, trypan blue exclusi...