Aromatic thiosemicarbazones, their antiviral action and interferon. 1. The decreasing of adenovirus type 1 resistance against interferon by methisazone in vitro

• Published in: Биополимеры и клетка
• Date: 1996
• Main Authors: Patskovsky, Y.V., Negrebetskaya, E.N., Chernomaz, A.A., Voloshchuk, T.P., Rubashevsky, E.L., Kitam, O.E., Tereshchenko, M.I., Nosach, L.N., Potopalsky, A.I.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 1996
• Subjects: Вирусы и клетка
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/153837
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Aromatic thiosemicarbazones, their antiviral action and interferon. 1. The decreasing of adenovirus type 1 resistance against interferon by methisazone in vitro / Y.V. Patskovsky, E.N. Negrebetskaya, A.A. Chernomaz, T.P. Voloshchuk, E.L. Rubashevsky, O.E. Kitam, M.I. Tereshchenko, L.N. Nosach, A.I. Potopalsky // Биополимеры и клетка. — 1996. — Т. 12, № 2. — С. 74-83. — Бібліогр.: 20 назв. — англ.

The mechanism of N-mvthyl-izatin-thiocarbazone (methisazone, MelBT) antiviral activity has been studied on Ad 1-infected HEp2 and HeLa cells. MelBT did not induce interferon and did not directly inhibit viraland cell translation. The adenoviral infection was not affected by recombinani human interfe...