Inhibition of in vitro transcription by 2-arylidene derivatives of thiazolo[3,2-α]benzimidazol-3(2H)-one

• Date: 2010
• Main Authors: Palchykovska, L.G., Alexeeva, I.V., Negrutska, V.V., Kostyuk, Yu.K., Indychenko, T.M., Kostenko, O.M., Kryvorotenko, D.V., Shved, A.D., Dubey, I.Ya.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2010
• Series: Вiopolymers and Cell
• Subjects: Bioorganic Chemistry
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154215
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Inhibition of in vitro transcription by 2-arylidene derivatives of thiazolo[3,2-α]benzimidazol-3(2H)-one / L.G. Palchykovska, I.V. Alexeeva, V.V. Negrutska, Yu.K. Kostyuk, T.M. Indychenko, O.M. Kostenko, D.V. Kryvorotenko, A.D. Shved, I.Ya. Dubey // Вiopolymers and Cell. — 2010. — Т. 26, № 6. — С. 508-511. — Бібліогр.: 19 назв. — англ.

Aim. To evaluate a series of 2-substituted thiazolo[3,2-α]benzimidazolones as potential transcription inhibitors. Methods. Compounds were tested in a model transcription system based on T7 RNA polymerase. Results. The testing revealed a number of compounds able to inhibit transcription at micromolar...