DNA-binding studies of a series of novel water-soluble derivatives of 1,4-dihydropyridine

• Published in: Вiopolymers and Cell
• Date: 2018
• Main Authors: Leonova, E., Rostoka, E., Baumane, L., Borisovs, V., Smelovs, E., Bisenieks, I., Brūvere, I., Bisenieks, E., Duburs, G., Sjakste, N.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2018
• Subjects: Bioorganic Chemistry
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154284
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: DNA-binding studies of a series of novel water-soluble derivatives of 1,4-dihydropyridine / E. Leonova, E. Rostoka, L. Baumane, V. Borisovs, E. Smelovs, I. Bisenieks, I. Brūvere, E. Bisenieks, G. Duburs, N. Sjakste // Вiopolymers and Cell. — 2018. — Т. 34, № 2. — С. 127-141. — Бібліогр.: 22 назв. — англ.

Aim. to determine DNA interaction modes for a series of 1,4-dihydropyridines with different biological activities synthesized in the Latvian Institute of Or-ganic Synthesis. Methods. Affinity of the compounds to DNA was detected by UV/VIS spec-trometry and re-proofed by means of spectrofluorimetry,...