PPM1M and PRICKLE2 are potential tumor suppressor genes in human clear-cell renal cell carcinoma

• Date: 2014
• Main Authors: Rudenko, E.E., Gerashchenko, G.V., Lapska, Y.V., Vozianov, S.O., Zgonnyk, Y.M., Kashuba, V.I.
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2014
• Series: Вiopolymers and Cell
• Subjects: Biomedicine
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/154299
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: PPM1M and PRICKLE2 are potential tumor suppressor genes in human clear-cell renal cell carcinoma / E.E. Rudenko, G.V. Gerashchenko, Y.V. Lapska, S.O. Vozianov, Y.M. Zgonnyk, V.I. Kashuba // Вiopolymers and Cell. — 2014. — Т. 30, № 3. — С. 229-233. — Бібліогр.: 11 назв. — англ.

Aim. To investigate the expression levels of PPM1M and PRICKLE2 in clear-cell renal cell carcinomas (ccRCC) and propose a mechanism leading to the expression changes in tumor. Methods. Analysis of GEO data, quantitative PCR (Q-PCR), bisulfite sequencing, methylation-specific PCR, deletion search. Re...