Interaction of cationic porphyrin-imidazophenazine conjugates with DNA quadruplex: FID assay and quantum-chemical modeling

Interaction of cationic porphyrin-imidazophenazine conjugates with DNA quadruplex: FID assay and quantum-chemical modeling

Aim. To study the efficiency of tricationic porphyrin–imidazo[4,5-b]phenazine conjugate and its Zn(II) and Mn(III) complexes as G-quadruplex (G4) DNA ligands. Methods. FID (Fluorescent Intercalator Displacement) assay was used to evaluate the affinity of compounds for a model duplex and Tel22 quadru...

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Datum:	2018
Hauptverfasser:	Didan, Yu.V., Ilchenko, M.M., Negrutska, V.V., Dubey, L.V., Ryazanova, O.A., Dubey, I.Ya.
Format:	Artikel
Sprache:	English
Veröffentlicht:	Інститут молекулярної біології і генетики НАН України 2018
Schriftenreihe:	Вiopolymers and Cell
Schlagworte:	Bioorganic Chemistry
Online Zugang:	https://nasplib.isofts.kiev.ua/handle/123456789/154345
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Назва журналу:	Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:	Interaction of cationic porphyrin-imidazophenazine conjugates with DNA quadruplex: FID assay and quantum-chemical modeling / Yu.V. Didan, M.M. Ilchenko, V.V. Negrutska, L.V. Dubey, O.A. Ryazanova, I.Ya. Dubey // Вiopolymers and Cell. — 2018. — Т. 34, № 5. — С. 387-399. — Бібліогр.: 56 назв. — англ.

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