Identification of 4‐methoxythieno[2,3‐d]pyrimidines as FGFR1 Inhibitors

• Veröffentlicht in: Вiopolymers and Cell
• Datum: 2019
• Hauptverfasser: Kotey, I.M., Protopopov, M.V., Starosyla, S.A., Balanda, A.O., Pletnova, L.V., Prykhod'ko, A.O., Bdzhola, V.G., Yarmoluk, S.M.
• Format: Artikel
• Sprache: English
• Veröffentlicht: Інститут молекулярної біології і генетики НАН України 2019
• Schlagworte: Bioorganic Chemistry
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/154386
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Identification of 4‐methoxythieno[2,3‐d]pyrimidines as FGFR1 Inhibitors / I.M. Kotey, M.V. Protopopov, S.A. Starosyla, A.O. Balanda, L.V. Pletnova, A.O. Prykhod'ko, V.G. Bdzhola, S.M. Yarmoluk // Вiopolymers and Cell. — 2019. — Т. 35, № 2. — С. 152-162. — Бібліогр.: 17 назв. — англ.

Aim. To identify novel FGFR1 inhibitors using virtual screening approach. Methods. We used methods of organic synthesis, molecular docking via the Autodock 4.2.6 program package and in vitro biochemical tests with γ-32P. Results. In vitro experiments showed that 9 of 23 tested compounds possess inhi...