Identification of 4‐methoxythieno[2,3‐d]pyrimidines as FGFR1 Inhibitors

Aim. To identify novel FGFR1 inhibitors using virtual screening approach. Methods. We used methods of organic synthesis, molecular docking via the Autodock 4.2.6 program package and in vitro biochemical tests with γ-32P. Results. In vitro experiments showed that 9 of 23 tested compounds possess inhi...

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Veröffentlicht in:Вiopolymers and Cell
Datum:2019
Hauptverfasser: Kotey, I.M., Protopopov, M.V., Starosyla, S.A., Balanda, A.O., Pletnova, L.V., Prykhod'ko, A.O., Bdzhola, V.G., Yarmoluk, S.M.
Format: Artikel
Sprache:English
Veröffentlicht: Інститут молекулярної біології і генетики НАН України 2019
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Online Zugang:https://nasplib.isofts.kiev.ua/handle/123456789/154386
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:Identification of 4‐methoxythieno[2,3‐d]pyrimidines as FGFR1 Inhibitors / I.M. Kotey, M.V. Protopopov, S.A. Starosyla, A.O. Balanda, L.V. Pletnova, A.O. Prykhod'ko, V.G. Bdzhola, S.M. Yarmoluk // Вiopolymers and Cell. — 2019. — Т. 35, № 2. — С. 152-162. — Бібліогр.: 17 назв. — англ.

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