Results on complex treatment of patients with glial tumors of brain with local chemotherapy
Aim. For the purpose of local chemotherapy in patients with malignant brain tumors after partial or total removal of tumors we used biodegradable film with methotrexate. The film, due to its properties, is firmly attached to the wound surface. With its composition of chemotherapeutic agents over sp...
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| Datum: | 2011 |
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| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Інститут молекулярної біології і генетики НАН України
2011
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| Schriftenreihe: | Вiopolymers and Cell |
| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/156375 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Results on complex treatment of patients with glial tumors of brain with local chemotherapy / L.R. Harutyunyan // Вiopolymers and Cell. — 2011. — Т. 27, № 5. — С. 373-376. — Бібліогр.: 7 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | Aim. For the purpose of local chemotherapy in patients with malignant brain tumors after partial or total removal of tumors we used biodegradable film with methotrexate. The film, due to its properties, is firmly attached to
the wound surface. With its composition of chemotherapeutic agents over specified time, the dosed film immediately affects diseased tissue, playing the role of a local chemotherapy depo. Methods. Results of treatment
of 74 patients with low differentiated gliomas of the brain, which have undergone a comprehensive treatment
that includes surgical removal of tumor and implantation of methotrexate depo in the wall of postoperative cerebral injury followed by radiotherapy in the pig on a bed of the tumor removed. Results. A retrospective analysis of
the results of complex treatment of patients with glial brain tumors with local chemotherapy showed a significant
increase in disease-free period in patients who have undergone, consistently, surgery, chemotherapy and adjuvant local radiation therapy. Conclusions. Our research has shown that the use of local chemotherapy greatly
improves the results of treatment of patients not only for total removal of intracerebral tumors, but also for subtotalremoval, as well asin patients with prolonged tumor growth, when there is no possibility ofradiation treatment.
Keywords: glial tumors, local chemotherapy, methotrexate, polymeric film. |
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