Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease

Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease

Increased levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) in plasma is associated with a reduced risk of developing cardiovascular diseases (CVD). In addition to its potential cardioprotective function, HDL and ApoA1, the main HDL apolipoprotein, also have antidi...

Full description

Saved in:
Bibliographic Details
Date:2021
Main Authors: Tronko, M.D., Cherviakova, S.A., Pushkarev, V.V., Belchina, Y.B., Kovzun, O.I., Pushkarev, V.M., Sokolova, L.K.
Format: Article
Language:English
Published: Видавничий дім "Академперіодика" НАН України 2021
Series:Доповіді НАН України
Subjects:
Біохімія
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/180577
Tags: Add Tag
No Tags, Be the first to tag this record!
Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease / M.D. Tronko, S.A. Cherviakova, V.V. Pushkarev, Y.B. Belchina, O.I. Kovzun, V.M. Pushkarev, L.K. Sokolova // Доповіді Національної академії наук України. — 2021. — № 4. — С. 110-113. — Бібліогр.: 10 назв. — англ.

Institution

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-180577
record_format dspace
fulltext
spelling nasplib_isofts_kiev_ua-123456789-1805772025-02-09T10:59:52Z Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease Рівень аполіпопротеїну А1 у плазмі крові хворих на цукровий діабет та хворих на цукровий діабет із COVID-19 як можливий маркер захворювання Tronko, M.D. Cherviakova, S.A. Pushkarev, V.V. Belchina, Y.B. Kovzun, O.I. Pushkarev, V.M. Sokolova, L.K. Біохімія Increased levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) in plasma is associated with a reduced risk of developing cardiovascular diseases (CVD). In addition to its potential cardioprotective function, HDL and ApoA1, the main HDL apolipoprotein, also have antidiabetic properties. The aim of the study was to determine the level of ApoA1 in the blood of patients (n = 81) with type 2 diabetes mellitus and COVID-19. ApoA1 was determined by enzyme-linked immunosorbent assay (ELISA) (Elabscience, USA). The measurements were performed at an optical density of 450 nm. We showed that the level of ApoA1 in the blood of patients with type 2 diabetes and especially with COVID-19 was significantly lower than in the blood of healthy people. Blood ApoA1 levels did not show a further decrease in patients with both COVID-19 and diabetes compared with patients with COVID-19 without diabetes. Thus, the level of ApoA1 may be one of the promising markers of severe COVID-19. Підвищений рівень холестерину ліпопротеїнів високої щільності (ЛПВЩ-Х) та аполіпопротеїну А1 (ApoA1) у плазмі асоціюється із зниженим ризиком розвитку серцево-судинних захворювань. Окрім потенційної кардіопротекторної функції, ЛПВЩ та АпоА1, основний аполіпопротеїн ЛПВЩ, також мають протидіабетичні властивості. Визначено рівень ApoA1 у крові хворих (n = 81) на цукровий діабет 2-го типу та COVID-19. ApoA1 визначали за допомогою набору для імуноферментного аналізу (ELISA) (Elabscience, США). Вимірювання проводили при оптичній довжині хвилі 450 нм. Показано, що рівень ApoA1 у крові хворих на цукровий діабет 2-го типу і, особливо, з COVID-19 був значно нижчим, ніж у крові здорових людей. Рівень ApoA1 у крові не демонструє подальшого зниження у пацієнтів як з COVID-19, так і з діабетом порівняно з хворими на COVID-19 без діабету. Рівень ApoA1 може бути одним із перспективних маркерів тяжкого перебігу COVID-19. 2021 Article Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease / M.D. Tronko, S.A. Cherviakova, V.V. Pushkarev, Y.B. Belchina, O.I. Kovzun, V.M. Pushkarev, L.K. Sokolova // Доповіді Національної академії наук України. — 2021. — № 4. — С. 110-113. — Бібліогр.: 10 назв. — англ. 1025-6415 DOI: doi.org/10.15407/dopovidi2021.04.110 https://nasplib.isofts.kiev.ua/handle/123456789/180577 616.12:575:577.112.856 en Доповіді НАН України application/pdf Видавничий дім "Академперіодика" НАН України
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
language English
topic Біохімія
Біохімія
spellingShingle Біохімія
Біохімія
Tronko, M.D.
Cherviakova, S.A.
Pushkarev, V.V.
Belchina, Y.B.
Kovzun, O.I.
Pushkarev, V.M.
Sokolova, L.K.
Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease
Доповіді НАН України
description Increased levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) in plasma is associated with a reduced risk of developing cardiovascular diseases (CVD). In addition to its potential cardioprotective function, HDL and ApoA1, the main HDL apolipoprotein, also have antidiabetic properties. The aim of the study was to determine the level of ApoA1 in the blood of patients (n = 81) with type 2 diabetes mellitus and COVID-19. ApoA1 was determined by enzyme-linked immunosorbent assay (ELISA) (Elabscience, USA). The measurements were performed at an optical density of 450 nm. We showed that the level of ApoA1 in the blood of patients with type 2 diabetes and especially with COVID-19 was significantly lower than in the blood of healthy people. Blood ApoA1 levels did not show a further decrease in patients with both COVID-19 and diabetes compared with patients with COVID-19 without diabetes. Thus, the level of ApoA1 may be one of the promising markers of severe COVID-19.
format Article
author Tronko, M.D.
Cherviakova, S.A.
Pushkarev, V.V.
Belchina, Y.B.
Kovzun, O.I.
Pushkarev, V.M.
Sokolova, L.K.
author_facet Tronko, M.D.
Cherviakova, S.A.
Pushkarev, V.V.
Belchina, Y.B.
Kovzun, O.I.
Pushkarev, V.M.
Sokolova, L.K.
author_sort Tronko, M.D.
title Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease
title_short Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease
title_full Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease
title_fullStr Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease
title_full_unstemmed Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease
title_sort apolipoprotein a1 level in plasma of patients with diabetes and diabetic patients with covid-19 as a possible marker of disease
publisher Видавничий дім "Академперіодика" НАН України
publishDate 2021
topic_facet Біохімія
url https://nasplib.isofts.kiev.ua/handle/123456789/180577
citation_txt Apolipoprotein A1 level in plasma of patients with diabetes and diabetic patients with COVID-19 as a possible marker of disease / M.D. Tronko, S.A. Cherviakova, V.V. Pushkarev, Y.B. Belchina, O.I. Kovzun, V.M. Pushkarev, L.K. Sokolova // Доповіді Національної академії наук України. — 2021. — № 4. — С. 110-113. — Бібліогр.: 10 назв. — англ.
series Доповіді НАН України
work_keys_str_mv AT tronkomd apolipoproteina1levelinplasmaofpatientswithdiabetesanddiabeticpatientswithcovid19asapossiblemarkerofdisease
AT cherviakovasa apolipoproteina1levelinplasmaofpatientswithdiabetesanddiabeticpatientswithcovid19asapossiblemarkerofdisease
AT pushkarevvv apolipoproteina1levelinplasmaofpatientswithdiabetesanddiabeticpatientswithcovid19asapossiblemarkerofdisease
AT belchinayb apolipoproteina1levelinplasmaofpatientswithdiabetesanddiabeticpatientswithcovid19asapossiblemarkerofdisease
AT kovzunoi apolipoproteina1levelinplasmaofpatientswithdiabetesanddiabeticpatientswithcovid19asapossiblemarkerofdisease
AT pushkarevvm apolipoproteina1levelinplasmaofpatientswithdiabetesanddiabeticpatientswithcovid19asapossiblemarkerofdisease
AT sokolovalk apolipoproteina1levelinplasmaofpatientswithdiabetesanddiabeticpatientswithcovid19asapossiblemarkerofdisease
AT tronkomd rívenʹapolípoproteínua1uplazmíkrovíhvorihnacukrovijdíabettahvorihnacukrovijdíabetízcovid19âkmožlivijmarkerzahvorûvannâ
AT cherviakovasa rívenʹapolípoproteínua1uplazmíkrovíhvorihnacukrovijdíabettahvorihnacukrovijdíabetízcovid19âkmožlivijmarkerzahvorûvannâ
AT pushkarevvv rívenʹapolípoproteínua1uplazmíkrovíhvorihnacukrovijdíabettahvorihnacukrovijdíabetízcovid19âkmožlivijmarkerzahvorûvannâ
AT belchinayb rívenʹapolípoproteínua1uplazmíkrovíhvorihnacukrovijdíabettahvorihnacukrovijdíabetízcovid19âkmožlivijmarkerzahvorûvannâ
AT kovzunoi rívenʹapolípoproteínua1uplazmíkrovíhvorihnacukrovijdíabettahvorihnacukrovijdíabetízcovid19âkmožlivijmarkerzahvorûvannâ
AT pushkarevvm rívenʹapolípoproteínua1uplazmíkrovíhvorihnacukrovijdíabettahvorihnacukrovijdíabetízcovid19âkmožlivijmarkerzahvorûvannâ
AT sokolovalk rívenʹapolípoproteínua1uplazmíkrovíhvorihnacukrovijdíabettahvorihnacukrovijdíabetízcovid19âkmožlivijmarkerzahvorûvannâ
first_indexed 2025-11-25T20:50:34Z
last_indexed 2025-11-25T20:50:34Z
_version_ 1849796941888618496

Similar Items