Активність Ca2+-залежних протеїнкіназ в епітеліоцитах слизової оболонки товстої кишки щурів за умов розвитку коліт-асоційованого канцерогенезу
The free cytoplasmic Ca²^+ content and Ca²^+-dependent protein kinase activities are investigated in membrane and cytosolic fractions of rat colonocyte under the development of an experimental model of colitis-associated carcinogenesis. The increase of free endocellular Ca²^+ by 2 times as compared...
Saved in:
| Date: | 2008 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | Ukrainian |
| Published: |
Видавничий дім "Академперіодика" НАН України
2008
|
| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/7522 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Активність Ca2+-залежних протеїнкіназ в епітеліоцитах слизової оболонки товстої кишки щурів за умов розвитку коліт-асоційованого канцерогенезу / О.О. Кравченко, О.В. Дробiнська, Л. I. Остапченко // Доп. НАН України. — 2008. — № 12. — С. 154-160. — Бібліогр.: 15 назв. — укр. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | The free cytoplasmic Ca²^+ content and Ca²^+-dependent protein kinase activities are investigated in membrane and cytosolic fractions of rat colonocyte under the development of an experimental model of colitis-associated carcinogenesis. The increase of free endocellular Ca²^+ by 2 times as compared with control during the formation and development of colon inflammation is shown. It is established that enzymes of Ser-Thr phosphorilation mediate ulcerative colitis-associated carcinogenesis. These enzyme activities increase and reach their peak values in cytosol in the second week for protein kinase C, the fourth one for Ca/calmodulin-depenent kinase, and the tenth week in the membrane fraction.
|
|---|---|
| ISSN: | 1025-6415 |