Кількісне визначення оксациліну методами кінетико-спектрофотометрії та окисно-відновного титрування

• Veröffentlicht in: Журнал органічної та фармацевтичної хімії
• Datum: 2023
• Jahrgang: 21
• Heft: 2
• Сторінки: 15-20
• ISSN: 2518-1548
• Автори та афіліації: Svetlana P. Karpova — National University of Pharmacy of the Ministry of Health of Ukraine; Maryna M. Ivashura — National University of Pharmacy of the Ministry of Health of Ukraine; Alla O. Koval — National University of Pharmacy of the Ministry of Health of Ukraine; Yulia S. Kolisnyk — National University of Pharmacy of the Ministry of Health of Ukraine
• Hauptverfasser: Karpova, Svetlana P., Ivashura, Maryna M., Koval, Alla O., Kolisnyk, Yulia S.
• Format: Artikel
• Sprache: Englisch
• Veröffentlicht: National University of Pharmacy 2023
• Schlagworte: оксацилін; калій гідрогенпероксомоносульфат; йодометрія; кінетико-спектрофотометрія
• Online Zugang: https://ophcj.nuph.edu.ua/article/view/273654
• Назва журналу: Journal of Organic and Pharmaceutical Chemistry

The search for new analytical reactions and finding out the optimal conditions for their course, which can be used as the basis for quantitative analytical determinations of penicillins, is a very urgent task.Aim. To develop methods for the quantitative determination of Oxacillin.Materials and methods. The study object was Oxacillin sodium salt powder in vials for preparing a solution for injections(0.5 g). Peroxomonosulfate acid as triple potassium salt 2КНSO5∙КНSO4∙K2SO4 (Oxone®) of “extra pure” grade was used as an oxidant. The methods of kinetic spectriphotometry and redox titration were used.Results and discussion. A simple procedure for the quantitative determination of the Oxacillin pure substance by the kinetic spectrophotometry and redox titration methods using potassium hydrogen peroxomonosulfate (KHSO5) has been developed. The results of the drug analysis obtained by newly developed and current methods are in good agreement with each other; δ (correctness) = (0.45 – 0.86) %.Conclusions. Using the methods of kinetic spectrophotometric and redox titration, two independent procedures for thequantitative determination of oxacillin in the substance and the drug product have been developed using potassium hydrogen peroxomonosulfate as an analytical reagent (KHSO5). A relative standard deviation RSD = (1.24 – 2.17) %.