Ефективний синтез інгібіторів PARP на основі 4-трифторометилзаміщеного скафолду 3,6,7,7a-тетрагідро-1H-піроло[3,4-d]піримідин-2,5-діону
Poly(ADP-ribose) polymerases (PARPs) are key enzymes in the DNA repair pathway. Inhibitors of these enzymes belong to a new type of anticancer drugs that selectively kill cancer cells by targeting the homologous recombination genetic defects. This study presents a new synthetic approach to PARP inhi...
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| Date: | 2023 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
National University of Pharmacy
2023
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| Subjects: | |
| Online Access: | https://ophcj.nuph.edu.ua/article/view/298727 |
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| Journal Title: | Journal of Organic and Pharmaceutical Chemistry |