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Синтез функціоналізованих диметилфосфіноїл циклопропанів і циклобутанів

Синтез функціоналізованих диметилфосфіноїл циклопропанів і циклобутанів

A simple preparative approach to a series of functionalized dimethylphosphinoyl-containing cyclopropanes and cyclobutanes has been developed; it is based on cyclocondensation of dimethylphosphinoyl acetonitrile with 1,2- and 1,3-dibromoalkanes. Synthetic procedures for obtaining nitriles, amines and...

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Bibliographic Details
Main Authors: Aleksandrova, Anastasiia M., Cherednichenko, Alona S., Rassukana, Yuliya V.
Format: Article
Language:English
Published: National University of Pharmacy 2023
Subjects:
диметилфосфіноксиди
циклопропан
циклобутан
аміни
карбонові кислоти
dimethylphosphine oxides
cyclopropane
cyclobutane
amines
carboxylic acids
Online Access:https://ophcj.nuph.edu.ua/article/view/299237
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Summary:A simple preparative approach to a series of functionalized dimethylphosphinoyl-containing cyclopropanes and cyclobutanes has been developed; it is based on cyclocondensation of dimethylphosphinoyl acetonitrile with 1,2- and 1,3-dibromoalkanes. Synthetic procedures for obtaining nitriles, amines and carboxylic acids containing in their structure small saturated cyclic rings of cyclopropane or cyclobutane and a dimethylphosphine oxide fragment, which are popular in drug design, have been developed.

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