Анелювання 1,2,4-триазинового ядра до 2,3-бензодіазепіну

• Date: 2025
• Main Authors: Bohdan, Natalia M., Shuvakin, Serhii I., Nechaieva, Diana S., Suikov, Sergii Yu., Bohza, Serhii L.
• Format: Article
• Language: English
• Published: National University of Pharmacy 2025
• Subjects: 2,3-бензодіазепін; α-кетоестер; 1,2,4-триазин; анелювання
• Online Access: https://ophcj.nuph.edu.ua/article/view/327856
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

A one-pot, stepwise method for the annelation of the 1,2,4-triazine core to the seven-membered 2,3-benzodiazepine ring via the interaction of the corresponding 2,3-benzodiazepin-1-yl- or 2,3-benzodiazepin-4-ylhydrazines with α-ketoesters has been developed. It has been found that a stepwise formatio...