Синтез (±)-(1R,6R,7R)-2-азабіцикло[4.2.0]октан-7-олу

• Date: 2026
• Main Authors: Nosyk, Danylo A., Lukyanenko, Serhii Yu., Granat, Dmytro S., Yurchenko, Oleksandr O., Grygorenko, Oleksandr O.
• Format: Article
• Language: English
• Published: National University of Pharmacy 2026
• Subjects: біциклічні сполуки; [2 2] циклоприєднання; лактами; будівельні блоки
• Online Access: https://ophcj.nuph.edu.ua/article/view/353627
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

 An approach to the synthesis of (±)-(1R,6R,7R)-2-azabicyclo[4.2.0]octan-7-ol, a promising amino alcohol building block for drug discovery, has been described. The method is based on [2+2] the cycloaddition of tert-butyl vinyl ether and a ketene generated in situ from a glutaric acid derivative, as...