ОÑобенноÑти апоптоза, индуцированного Ñнижением температуры
We summarised and analysed here the findings on apoptosis contribution into the cell damages, caused by temperature deviation from the physiological norm (below 37°C). The participation of the caspases, causing the disintegration of anti-apoptotic Bcl-2 family proteins and proteolysis of the DNAase...
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| Date: | 2017 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine
2017
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| Subjects: | |
| Online Access: | https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1290 |
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| Journal Title: | Problems of Cryobiology and Cryomedicine |
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Problems of Cryobiology and Cryomedicine| Summary: | We summarised and analysed here the findings on apoptosis contribution into the cell damages, caused by temperature deviation from the physiological norm (below 37°C). The participation of the caspases, causing the disintegration of anti-apoptotic Bcl-2 family proteins and proteolysis of the DNAase inhibitor, responsible for DNA fragmentation in the apoptosis, induced by a moderate cell cooling, was shown. An important role in cold adaptation mechanism belongs to the RNA-binding protein (cold-inducible RNAbinding protein, CIRP), which is capable to prevent the oxidative stress-induced apoptosis development. We reported here the data, confirming the participation of reactive oxygen species and antioxidant cell components: superoxide dismutase and human peroxiredoxin 1 in apoptosis and cold adaptation.Probl Cryobiol Cryomed 2017; 27(2): 97–109 |
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