Вплив низькомолекулÑрної фракції (до 5 кДа) кордової крові людини на роÑтові влаÑтивоÑÑ‚Ñ– культурі мезенхімальних Ñтромальних клітин, Ñкі були піддані кріоконÑервуванню
The influence of cryopreservation on growth properties, immune phenotype and differentiation potential of mesenchymal stromal cells (MSCs) of human and rat was investigated, as well as the ability of human cord blood fractions below 5 kD (hCBF) to affect these indices in thawed cultures. It has...
Збережено в:
| Дата: | 2018 |
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| Автори: | , , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine
2018
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| Теми: | |
| Онлайн доступ: | https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1431 |
| Теги: |
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| Назва журналу: | Problems of Cryobiology and Cryomedicine |
Репозитарії
Problems of Cryobiology and Cryomedicine| Резюме: | The influence of cryopreservation on growth properties, immune phenotype and differentiation potential of mesenchymal stromal cells (MSCs) of human and rat was investigated, as well as the ability of human cord blood fractions below 5 kD (hCBF) to affect these indices in thawed cultures. It has been established that introduction of the hCBF with the concentration of 256-400 µg/ml to rat MSCs (rMSCs) culture caused the normalization of the cells growth properties reduced after cryopreservation that was not observed in human MSCs (hMSCs) culture. It has been shown that neither cryopreservation nor hCBF change the immune phenotype and ability for multi-lineage differentiation of hMSCs and rMSCs. The efficiency of low molecular weight fraction dependent on physiological characteristics of cells and its concentration in culture medium was concluded.Probl Cryobiol Cryomed 2018; 28(2): 131–138 |
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