Імунологічні особливості кріоаблації під час комплексного лікування онкологічних захворювань

• Date: 2019
• Main Authors: Goltsev, Anatoliy M., Bondarovych, Mykola O., Dubrava, Tatiana G., Babenko, Natalya M., Gaevska, Yuliya O., Ostankov, Maksim V., Buriak, Iryna A.
• Format: Article
• Language: English
• Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2019
• Subjects: кріоаблація; ракові стовбурові клітини; імунна система; антиген; дендритні клітини
• Online Access: https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1558
• Journal Title: Problems of Cryobiology and Cryomedicine

Cryoablation is a method of choice in treatment of solid tumors of different localization. In addition to the destruction of pathological tissue, the cryoablation causes to complex changes in the immune system. This paper briefly discusses the implementation of the abscopic effect after cryosurgery of tumors, as well as possible changes in the immune system that accompany it. The abscopic effect is achieved with a release of antigens from the destroyed cells, which trigger a cascade of immune reactions. This article summarizes the results of the combined use of cryoablation and immunotherapeutic methods, in particular adoptive therapy. The introduction of dendritic cells in combination with cryoablation can significantly enhance antitumor immunity and reduces the risk of relapse. Probl Cryobiol Cryomed 2019; 29(4): 297-302