ВлиÑние диметилÑульфокÑида и диÑтилÑульфокÑида на термичеÑкую денатурацию человечеÑкого Ñывороточного альбумина
The effect of dimethyl sulfoxide (DMSO) and diethyl sulfoxide (DESO) on thermal (heat and cold) denaturation of human serum albumin within temperature range from –20 to90°Cwas investigated by electron and fluorescent spectroscopy. It has been established that at heat induced denaturation in the p...
Збережено в:
| Дата: | 2009 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine
2009
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| Теми: | |
| Онлайн доступ: | https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/280 |
| Теги: |
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| Назва журналу: | Problems of Cryobiology and Cryomedicine |
Репозитарії
Problems of Cryobiology and Cryomedicine| Резюме: | The effect of dimethyl sulfoxide (DMSO) and diethyl sulfoxide (DESO) on thermal (heat and cold) denaturation of human serum albumin within temperature range from –20 to90°Cwas investigated by electron and fluorescent spectroscopy. It has been established that at heat induced denaturation in the presence of DESO an acid-neutral transition was observed at 47.61°C. It was shown that at cold induced denaturation the direct hydrophobic interactions of sulphoxide molecules with protein surface result in the formation of stable “ice†layer, providing the protein protection from irreversible structure changes. |
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