A study on the nature of nanosilica effect on celluar objects

• Datum: 2008
• Hauptverfasser: Krupska, T. V., Barvinchenko, V. N., Turov, V. V.
• Format: Artikel
• Sprache: Russisch
• Veröffentlicht: Chuiko Institute of Surface Chemistry National Academy of Sciences of Ukraine 2008
• Online Zugang: https://surfacezbir.com.ua/index.php/surface/article/view/311
• Назва журналу: Surface

Immobilization of levomicetin onto silica surface has been carried out by the method of impregnation from alcohol solutions. Molecular interactions in the system of levomicetin/water/silica were studied by a complex of experimental methods (1H NMR, IR, UV spectroscopy). The interface water layer structures and their thermodynamic parameters were found to depend on the levomicetin concentration. An effect was found of cell/silica interface on the formation of bound water layers in low hydration systems. The effect has been examined of the nanocomposites obtained and parent substances on cellular test systems. The optimum concentration of antibiotic in nanocomposite was shown to be within 0.4 to 0.6 mmol/g where pathogenic microorganisms are depressed to the maximum. The microporous co-polymer of styrenedyvinylbenzene was used as a model of intracellular space of partly dehydratd cells for measuring the statee of interface water and testing the influence of some organic molecules (DMSO, CHCl3, CH4) by the method of 1H NMR  spectroscopy. The effect was recognized of structural and energetic heterogeneity of water in the pores of polymer.