Исследование апоптотических процессов в клетках моноцитарно-фагоцитарной системы при развитии адъювантного артрита до и после введения криоконсервированных клеток фетальной печени

Исследование апоптотических процессов в клетках моноцитарно-фагоцитарной системы при развитии адъювантного артрита до и после введения криоконсервированных клеток фетальной печени

Rheumatoid arthritis (RA) is one of the most widespread chronic inflammatory diseases of the joints with multifactor etiology. A crucial point in RA is the disorder of proliferation and apoptosis in immunocompetent cells as well as in the cells of monocyte-phagocyte system (MPS). Using the model of...

Full description

Saved in:
Bibliographic Details
Date:2014
Main Authors: Goltsev, Anatoliy N., Yampolskaya, Ekaterina E., Ostankov, Maksim V., Bondarovich, Nikolay A.
Format: Article
Language:English
Published: Publishing House ‘Akademperiodyka’ of the National Academy of Sciences of Ukraine; Institute for Problems of Cryobiology and Cryomedicine 2014
Subjects:
апоптоз
моноцитарно-фагоцитарна система
ад'ювантний артрит
клітини фетальної печінки
кріоконсервування
Online Access:https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/719
Tags: Add Tag
No Tags, Be the first to tag this record!
Journal Title:Problems of Cryobiology and Cryomedicine

Institution

Problems of Cryobiology and Cryomedicine
Description
Summary:Rheumatoid arthritis (RA) is one of the most widespread chronic inflammatory diseases of the joints with multifactor etiology. A crucial point in RA is the disorder of proliferation and apoptosis in immunocompetent cells as well as in the cells of monocyte-phagocyte system (MPS). Using the model of adjuvant arthritis (AA) in animals we comparatively assessed the development of apoptotic processes in MPS cells before and after administration of native and cryopreserved fetal liver cells (cFLCs). By means of Western blot analysis we showed the peculiarities of CD-95 cascade proteins expression in MPS cells during development of AA. After administration of cFLCs we found more pronounced proapoptotic effect, which degree depended on the period of theiradministration.Probl Cryobiol Cryomed 2014; 24(3):249-261.

Similar Items