Synthesis and Antimicrobial Activity of 4-Arylthio- and 4 Alkylthiofunctionalized Pyrazolo[1,5-a]pyrazines

• Date: 2019
• Main Authors: Hrynyshyn, Yevhenii, Musiichuk, Hanna, Komarovska-Porokhnyavets, Olena, Is’kiv, Oksana, Moskalenko, Nataliia, Stasevych, Maryna, Tsyzoryk, Nazar, Vovk, Mykhailo
• Format: Article
• Language: English
• Published: V.I.Vernadsky Institute of General and Inorganic Chemistry 2019
• Online Access: https://ucj.org.ua/index.php/journal/article/view/22
• Journal Title: Ukrainian Chemistry Journal

The reaction of pyrazolo[1,5-a]pyrazine-4(5H)ones with phosphorus tribromoxide in boiling benzene yielded 4-bromopyrazolo[1,5-a]pyrazines, and the thionation with phosphorus pentasulfide in pyridine at 90 °C led to pyrazolo[1,5-a]pyrazine-4(5H)thiones. The synthesized bromine derivatives are electro...