POLYLECTROLYTE COMPLEX OF SODIUM ALGINATE - POLYETHYLENIMINE WITH THE INCLUSION COMPLEX OF SULFOBUTYL ETHER β-CYCLODEXTRIN – DEXAMETHASONE.

• Datum: 2023
• Hauptverfasser: Kobrina, Larisa, Boiko, Valentina, Riabov, Serhii, Stompel, Volodumir, Sinelnikov, Serhii
• Format: Artikel
• Sprache: English
• Veröffentlicht: V.I.Vernadsky Institute of General and Inorganic Chemistry 2023
• Online Zugang: https://ucj.org.ua/index.php/journal/article/view/615
• Назва журналу: Ukrainian Chemistry Journal

A polyelectrolyte complex (PEC) of sodium alginate with polyethyleneimine, loaded with (5 wt.%) inclusion complex (IC) of sulfobutylether β-cyclodextrin with dexame­thasone, was formed from aqueous solutions. Dexamethasone (DM) is a medical and ve­terinary synthetic glucocorticosteroid with anti-inflammatory and immunosuppressive effects, used in the treatment of various di­seases. The structure of the obtained compositions was analyzed by X-ray diffraction method, confirming the interaction PEC and IC through both Coulombic forces between the ionic groups of PEC and hydrogen bonding involving the proton-donor and proton-acceptor polar groups of PEC and IC. These findings were supported by pyrolytic mass spectrometry data and differential scanning calorimetry. The decrease in PEC swelling degree further supports the above conclusions. Testing the obtained PEC films  for drug release using UV spectrophotometry revealed that the release kinetics were nonlinear and partially dependent on the release medium, indicating their potential as materials for creating polymer matrices with prolonged therapeutic effects.