MECHANOCHEMICAL SYNTHESIS OF FLUORINE-CONTAINING HETEROCYCLES VIA BALL MILLING
Fluorine-containing heterocycles play a crucial role in the pharmaceutical, agrochemical, and materials industries. The pursuit of effective and sustainable synthesis methods has driven the development of mechanochemistry as a solvent-free, energy-efficient alternative to conventional chemical trans...
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| Datum: | 2025 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
V.I.Vernadsky Institute of General and Inorganic Chemistry
2025
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| Online Zugang: | https://ucj.org.ua/index.php/journal/article/view/738 |
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| Назва журналу: | Ukrainian Chemistry Journal |
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Ukrainian Chemistry Journal| Zusammenfassung: | Fluorine-containing heterocycles play a crucial role in the pharmaceutical, agrochemical, and materials industries. The pursuit of effective and sustainable synthesis methods has driven the development of mechanochemistry as a solvent-free, energy-efficient alternative to conventional chemical transformations. Among these approaches, ball milling has emerged as a particularly promising technique for facilitating chemical reactions. This review covers key achievements over the past decade in the mechanochemical synthesis of fluorinated heterocyclic compounds for bimolecular, trimolecular, and tetramolecular reactions as well as transformations classified as peripheral functionalization of the heterocyclic framework. This work serves as a valuable resource for researchers and practitioners seeking to develop sustainable and efficient catalytic systems for fluorinated heterocyclic synthesis. |
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