Синтез N-ацилсульфонамідів: від загальновідомих реакцій ацилювання до сучасних каталітичних і сталих методів

• Date: 2025
• Author Affiliations: Oleksii V. Gavrylenko — Enamine Ltd., Kyiv, Ukraine; Bohdan S. Sosunovych — Enamine Ltd., Kyiv, Ukraine; Bohdan V. Vashchenko — Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Enamine Scientific Research Institute (SRI), Kyiv, Ukraine; Oleksandr O. Grygorenko — Enamine Ltd., Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Enamine Scientific Research Institute (SRI), Kyiv, Ukraine; Yurii S. Moroz — Enamine Ltd., Kyiv, Ukraine; Enamine Scientific Research Institute (SRI), Kyiv, Ukraine; Chemspace LLC, Kyiv, Ukraine
• Keywords: keywords
• Main Authors: Gavrylenko, Oleksii V., Sosunovych, Bohdan S., Vashchenko, Bohdan V., Grygorenko, Oleksandr O., Moroz, Yurii S.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2025
• Subjects: N-ацилсульфонаміди; зелена хімія; каталіз; біоізостери
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/103
• Journal Title: Ukrainica Bioorganica Acta

N-Acyl sulfonamides are widely used bioisosteres of carboxylic acids, valued for their favorable physicochemical and pharmacokinetic properties as well as their frequent occurrence in drug-like molecules. This review summarizes the principal synthetic approaches to these motifs, covering both establ...