Синтез нових α-гідроксифосфонових кислот - фосфорних аналогів гомопроліну

• Date: 2025
• Main Authors: Kolodiazhna, Anastasiia O., Prysiazhnuk, Dmytro V., Gryshkun, Yevgen V.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2025
• Subjects: α-гідроксифосфонова кислота; фосфорні аналоги амінокислот; реакція Абрамова; біологічна активність
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/125
• Journal Title: Ukrainica Bioorganica Acta

A synthetic approach has been developed for the preparation of new bioisosteres of homoproline, namely α-hydroxyphosphonic acids. At the key stages of the synthesis, the phosphorylation of carbonyl derivatives of (S)- and (R)-proline via the Abramov reaction was employed. The resulting α-hydroxyphos...