Синтез та протиракова активність 2,5-діарил-оксазоло[5,4-d]піримідин-7-амінів та відповідних амідів

• Date: 2025
• Author Affiliations: Stepan G. Pilyo — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Maryna V. Kachaeva — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Serhii V. Popilnichenko — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Volodymyr S. Brovarets — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
• Keywords: keywords
• Main Authors: Pilyo, Stepan G., Kachaeva, Maryna V., Popilnichenko, Serhii V., Brovarets, Volodymyr S.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2025
• Subjects: оксазоло[5,4-d]піримідин-7-амін; аміди; протипухлинна активність
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/127
• Journal Title: Ukrainica Bioorganica Acta

A series of novel oxazolo[5,4-d]pyrimidine derivatives were synthesized and evaluated for anticancer activity against NCI 60 cancer cell lines. This work is a continuation of our investigation of the anticancer activity of a number of isomeric oxazolopyrimidines, and the study of the dependence of s...