Інгібування глутатіон-S-трансфераз калікс[4]аренфосфіновими кислотами

• Date: 2022
• Author Affiliations: Oleksandr L. Kobzar — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Yuriy V. Shulha — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Vladyslav M. Buldenko — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Andriy B. Drapailo — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02094, Ukraine; Vitaly I. Kalchenko — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine, 5 Murmanska St., Kyiv, 02094, Ukraine; Andriy I. Vovk — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine
• Keywords: keywords
• Main Authors: Kobzar, Oleksandr L., Shulha, Yuriy V., Buldenko, Vladyslav M., Drapailo, Andriy B., Kalchenko, Vitaly I., Vovk, Andriy I.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2022
• Subjects: фосфінові кислоти; калікс[4]арен; тіакалікс[4]арен; сульфонілкалікс[4]арен; глутатіон-S-трансфераза; інгібування; молекулярний докінг
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/16
• Journal Title: Ukrainica Bioorganica Acta

Calix[4]arene-, thiacalix[4]arene- and sulfonylcalix[4]arene-based derivatives with upper rim phosphinic acid groups were studied as inhibitors of glutathione S-transferases. It was found that the macrocyclic compounds can exhibit good to potent activity against GST from equine liver and human recom...