Нітрозаміщені аурони як інгібітори ксантиноксидази

• Date: 2021
• Main Authors: Kobzar, Oleksandr L., Mischenko, Iryna M., Tatarchuk, Alona V., Vdovin, Vasyl S., Lukashov, Sergiy S., Yarmoluk, Sergiy M., Vovk, Andriy I.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2021
• Subjects: аурони; ксантиноксидаза; інгібування; кінетика; молекулярний докінг
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/21
• Journal Title: Ukrainica Bioorganica Acta

Aurone derivatives possessing a wide range of biological activities are of high interest in medicinal chemistry. Carboxylated aurones were found previously to inhibit xanthine oxidase, which is a potential target for treatment of hyperuricemia and gout. In this paper, a series of B-ring nitro-substi...