Нітрозаміщені аурони як інгібітори ксантиноксидази

• Datum: 2021
• Автори та афіліації: Oleksandr L. Kobzar — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Iryna M. Mischenko — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Alona V. Tatarchuk — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine; Vasyl S. Vdovin — Institute of Molecular Biology and Genetics of the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine; Sergiy S. Lukashov — Institute of Molecular Biology and Genetics of the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine; Sergiy M. Yarmoluk — Institute of Molecular Biology and Genetics of the NAS of Ukraine, 150 Zabolotnogo St., Kyiv, 03143, Ukraine; Andriy I. Vovk — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, 1 Murmanska St., Kyiv, 02094, Ukraine
• Ключові слова: keywords
• Hauptverfasser: Kobzar, Oleksandr L., Mischenko, Iryna M., Tatarchuk, Alona V., Vdovin, Vasyl S., Lukashov, Sergiy S., Yarmoluk, Sergiy M., Vovk, Andriy I.
• Format: Artikel
• Sprache: Englisch
• Veröffentlicht: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2021
• Schlagworte: аурони; ксантиноксидаза; інгібування; кінетика; молекулярний докінг
• Online Zugang: https://bioorganica.com.ua/index.php/journal/article/view/21
• Назва журналу: Ukrainica Bioorganica Acta

Aurone derivatives possessing a wide range of biological activities are of high interest in medicinal chemistry. Carboxylated aurones were found previously to inhibit xanthine oxidase, which is a potential target for treatment of hyperuricemia and gout. In this paper, a series of B-ring nitro-substi...