Cинтез та протипухлинна активність 5-сульфонільних похідних 1,3-оксазол-4-карбоксилатів

• Main Authors: Pilyo, Stepan G., Kozachenko, Оlexandr P., Zhirnov, Victor V., Kachaeva, Maryna V., Kobzar, Oleksandr L., Vovk, Andriy I., Brovarets, Volodymyr S.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2020
• Subjects: 5-sulfonyl-1,3-oxazole-4-carboxylates; synthesis; anticancer activity; selectivity; molecular docking; 5-сульфоніл-1,3-оксазол-4-карбоксилати; синтез; протипухлинна активність; селективність; молекулярний докінг
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/36

A series of new 2-aryl 5-sulfonyl-1,3-oxazole-4-carboxylates for NCI anticancer screening protocol against 60 cancer cell lines were synthesized. Screening was performed in vitro on 60 cell lines of lungs, kidneys, CNS, ovaries, prostate, and breast cancer, leukemia, and melanoma. Methyl 5-benzylsul...