Класифікація конформацій сайтів зв’язування тирозинфосфатази 1B

• Видавець: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
• Дата: 2024
• Автори: Tanchuk, Vsevolod Y., Kobzar, Olexandr L., Vovk, Andriy I.
• Формат: Стаття
• Опубліковано: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2024
• Теми: PTP1B; binding sites; conformations; clustering; structure similarity
• Онлайн доступ: https://bioorganica.com.ua/index.php/journal/article/view/84

Our previous work on classification of binding site conformations of protein tyrosine phosphatase 1B was published in 2012. It was found that 102 active sites from 91 PDB files can be divided into 5 major clusters. The number of structures in the RSCB Protein data bank has almost tripled since that...