Перегляд класифікації конформацій активного центру протеїнтирозинфосфатази 1B

• Date: 2024
• Main Authors: Tanchuk, Vsevolod Y., Kobzar, Olexandr L., Vovk, Andriy I.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2024
• Subjects: PTP1B; активні центри; конформації; кластернізація; структурна подібність
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/84
• Journal Title: Ukrainica Bioorganica Acta

Our previous work on the classification of binding site conformations of protein tyrosine phosphatase 1B was published in 2012. It was then found that 102 active sites from 91 PDB files can be divided into 5 major clusters. Since that time, the number of the enzyme PDB files, which are deposited in...