ЕКСПРЕСІЯ ГЕНІВ РОДИНИ MRPS18 В ГЛІОМАХ
Summary. Aim: To assess expression patterns of MRPS18 family genes in glioblastoma tissues and glioma cell lines. Materials and Methods: Expression of MRPS18 family genes was analyzed by quantitative polymerase chain reaction in glioma cell lines and glioblastoma specimens. A bioin...
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| Date: | 2023 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
PH Akademperiodyka
2023
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| Subjects: | |
| Online Access: | https://exp-oncology.com.ua/index.php/Exp/article/view/2021-3-6 |
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| Journal Title: | Experimental Oncology |
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Experimental Oncology| Summary: | Summary. Aim: To assess expression patterns of MRPS18 family genes in glioblastoma tissues and glioma cell lines. Materials and Methods: Expression of MRPS18 family genes was analyzed by quantitative polymerase chain reaction in glioma cell lines and glioblastoma specimens. A bioinformatic analysis of the publicly available data on the expression of these genes was also provided. Results: The genes of MRPS18 family show different expression patterns in glioblastomas and glioma cell lines. The highest levels of expression were found for MRPS18-2 at mRNA and protein levels in both glioblastomas and glioma cell lines; the lowest — for MRPS18-1 at mRNA level. Conclusions: The elevated levels of relative expression of the MRPS18-2 gene are characteristic for glioma tumor tissues and cell lines. |
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