Plasminogen/plasmin affects expression of glycolysis regulator TIGAR and induces autophagy in lung adenocarcinoma A549 cells

Plasminogen/plasmin affects expression of glycolysis regulator TIGAR and induces autophagy in lung adenocarcinoma A549 cells

Summary. Pericellular plasmin generation triggers apoptosis/anoikis in normal adherent cells. However, cancer cells are notoriously resistant to anoikis, enabling metastasis and new tumor growth beyond their original environment. Autophagy can be a major contributor to anoikis resistance in cancer....

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Datum:2023
Hauptverfasser: Tykhomyrov, A.A., Nedzvetsky, V.S., Aĝca, C.A., Guzyk, M.M., Korsa, V.V., Grinenko, T.V.
Format: Artikel
Sprache:English
Veröffentlicht: PH Akademperiodyka 2023
Schlagworte:
anoikis
autophagy
beclin-1
LC3
plasminogen/plasmin
TIGAR
Online Zugang:https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-4
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Назва журналу:Experimental Oncology

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Experimental Oncology

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https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-4

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