Plasminogen/plasmin affects expression of glycolysis regulator TIGAR and induces autophagy in lung adenocarcinoma A549 cells

• Дата: 2023
• Автори: Tykhomyrov, A.A., Nedzvetsky, V.S., Aĝca, C.A., Guzyk, M.M., Korsa, V.V., Grinenko, T.V.
• Формат: Стаття
• Мова: English
• Опубліковано: PH Akademperiodyka 2023
• Теми: anoikis; autophagy; beclin-1; LC3; plasminogen/plasmin; TIGAR
• Онлайн доступ: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-4
• Назва журналу: Experimental Oncology

Summary. Pericellular plasmin generation triggers apoptosis/anoikis in normal adherent cells. However, cancer cells are notoriously resistant to anoikis, enabling metastasis and new tumor growth beyond their original environment. Autophagy can be a major contributor to anoikis resistance in cancer....