Plasminogen/plasmin affects expression of glycolysis regulator TIGAR and induces autophagy in lung adenocarcinoma A549 cells

• Date: 2023
• Main Authors: Tykhomyrov, A.A., Nedzvetsky, V.S., Aĝca, C.A., Guzyk, M.M., Korsa, V.V., Grinenko, T.V.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: anoikis; autophagy; beclin-1; LC3; plasminogen/plasmin; TIGAR
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-4
• Journal Title: Experimental Oncology

Summary. Pericellular plasmin generation triggers apoptosis/anoikis in normal adherent cells. However, cancer cells are notoriously resistant to anoikis, enabling metastasis and new tumor growth beyond their original environment. Autophagy can be a major contributor to anoikis resistance in cancer....