Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma

Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma

Summary. Aim: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and Methods: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was c...

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Datum:2023
Hauptverfasser: Onyshchenko, K.V., Voitsitskyi, T.V., Grygorenko, V.M., Saidakova, N.O., Pereta, L.V., Onyschuk, A.P., Skrypkina, I.Ya.
Format: Artikel
Sprache:English
Veröffentlicht: PH Akademperiodyka 2023
Schlagworte:
miR-138-1
miR-30s-5p
miRNA expression
renal cell carcinoma
Online Zugang:https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-6
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Назва журналу:Experimental Oncology

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Experimental Oncology
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spelling oai:ojs2.ex.aqua-time.com.ua:article-1892023-10-11T16:43:03Z Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma Onyshchenko, K.V. Voitsitskyi, T.V. Grygorenko, V.M. Saidakova, N.O. Pereta, L.V. Onyschuk, A.P. Skrypkina, I.Ya. miR-138-1, miR-30s-5p, miRNA expression, renal cell carcinoma miR-138-1, miR-30s-5p, miRNA expression, renal cell carcinoma Summary. Aim: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and Methods: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. Results: We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. Conclusions: A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers. Summary. Aim: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and Methods: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. Results: We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. Conclusions: A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers. PH Akademperiodyka 2023-06-01 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-6 10.32471/exp-oncology.2312-8852.vol-42-no-2.14632 Experimental Oncology; Vol. 42 No. 2 (2020): Experimental Oncology; 115-119 Експериментальна онкологія; Том 42 № 2 (2020): Експериментальна онкологія; 115-119 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-2 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-6/2020-2-6 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/
institution Experimental Oncology
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datestamp_date 2023-10-11T16:43:03Z
collection OJS
language English
topic miR-138-1
miR-30s-5p
miRNA expression
renal cell carcinoma
spellingShingle miR-138-1
miR-30s-5p
miRNA expression
renal cell carcinoma
Onyshchenko, K.V.
Voitsitskyi, T.V.
Grygorenko, V.M.
Saidakova, N.O.
Pereta, L.V.
Onyschuk, A.P.
Skrypkina, I.Ya.
Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma
topic_facet miR-138-1
miR-30s-5p
miRNA expression
renal cell carcinoma
miR-138-1
miR-30s-5p
miRNA expression
renal cell carcinoma
format Article
author Onyshchenko, K.V.
Voitsitskyi, T.V.
Grygorenko, V.M.
Saidakova, N.O.
Pereta, L.V.
Onyschuk, A.P.
Skrypkina, I.Ya.
author_facet Onyshchenko, K.V.
Voitsitskyi, T.V.
Grygorenko, V.M.
Saidakova, N.O.
Pereta, L.V.
Onyschuk, A.P.
Skrypkina, I.Ya.
author_sort Onyshchenko, K.V.
title Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma
title_short Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma
title_full Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma
title_fullStr Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma
title_full_unstemmed Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma
title_sort expression of micro-rna hsa-mir-30c-5p and hsa-mir-138-1 in renal cell carcinoma
title_alt Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma
description Summary. Aim: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and Methods: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. Results: We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. Conclusions: A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers.
publisher PH Akademperiodyka
publishDate 2023
url https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-6
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