Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma
Summary. Aim: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and Methods: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was c...
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| Date: | 2023 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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PH Akademperiodyka
2023
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| Online Access: | https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-6 |
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| Journal Title: | Experimental Oncology |
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Experimental Oncology| _version_ | 1856543503271591936 |
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| author | Onyshchenko, K.V. Voitsitskyi, T.V. Grygorenko, V.M. Saidakova, N.O. Pereta, L.V. Onyschuk, A.P. Skrypkina, I.Ya. |
| author_facet | Onyshchenko, K.V. Voitsitskyi, T.V. Grygorenko, V.M. Saidakova, N.O. Pereta, L.V. Onyschuk, A.P. Skrypkina, I.Ya. |
| author_sort | Onyshchenko, K.V. |
| baseUrl_str | |
| collection | OJS |
| datestamp_date | 2023-10-11T16:43:03Z |
| description | Summary. Aim: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and Methods: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. Results: We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. Conclusions: A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers. |
| first_indexed | 2025-07-17T12:16:17Z |
| format | Article |
| id | oai:ojs2.ex.aqua-time.com.ua:article-189 |
| institution | Experimental Oncology |
| language | English |
| last_indexed | 2025-07-17T12:16:17Z |
| publishDate | 2023 |
| publisher | PH Akademperiodyka |
| record_format | ojs |
| spelling | oai:ojs2.ex.aqua-time.com.ua:article-1892023-10-11T16:43:03Z Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma Onyshchenko, K.V. Voitsitskyi, T.V. Grygorenko, V.M. Saidakova, N.O. Pereta, L.V. Onyschuk, A.P. Skrypkina, I.Ya. miR-138-1, miR-30s-5p, miRNA expression, renal cell carcinoma miR-138-1, miR-30s-5p, miRNA expression, renal cell carcinoma Summary. Aim: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and Methods: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. Results: We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. Conclusions: A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers. Summary. Aim: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and Methods: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. Results: We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. Conclusions: A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers. PH Akademperiodyka 2023-06-01 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-6 10.32471/exp-oncology.2312-8852.vol-42-no-2.14632 Experimental Oncology; Vol. 42 No. 2 (2020): Experimental Oncology; 115-119 Експериментальна онкологія; Том 42 № 2 (2020): Експериментальна онкологія; 115-119 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-2 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-6/2020-2-6 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| spellingShingle | miR-138-1 miR-30s-5p miRNA expression renal cell carcinoma Onyshchenko, K.V. Voitsitskyi, T.V. Grygorenko, V.M. Saidakova, N.O. Pereta, L.V. Onyschuk, A.P. Skrypkina, I.Ya. Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma |
| title | Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma |
| title_alt | Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma |
| title_full | Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma |
| title_fullStr | Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma |
| title_full_unstemmed | Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma |
| title_short | Expression of micro-RNA hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma |
| title_sort | expression of micro-rna hsa-mir-30c-5p and hsa-mir-138-1 in renal cell carcinoma |
| topic | miR-138-1 miR-30s-5p miRNA expression renal cell carcinoma |
| topic_facet | miR-138-1 miR-30s-5p miRNA expression renal cell carcinoma miR-138-1 miR-30s-5p miRNA expression renal cell carcinoma |
| url | https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-6 |
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