Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells

• Datum: 2023
• Hauptverfasser: Antonenko, S.V., Telegeev, G.D.
• Format: Artikel
• Sprache: English
• Veröffentlicht: PH Akademperiodyka 2023
• Schlagworte: Bcr-Abl oncoprotein; chronic myeloid leukemia; K562 cells; ML323 inhibitor; USP1 protein
• Online Zugang: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-10
• Назва журналу: Experimental Oncology

Summary. Aim: To analyze interaction of ubiquitin specific peptidase 1 (USP1) with Bcr-Abl and to assess the relation between USP1 functional activity and Bcr-Abl expression in K562 chronic myeloid leukemia cells. Materials and Methods: The interaction between USP1 and Bcr-Abl in K562&n...