Sensitivity of chronic lymphocytic leukemia cells to chemotherapeutic drugs ex vivo depends on expression status of cell surface receptors

• Date: 2023
• Main Authors: Shcherbina, V., Gordiienko, I., Shlapatska, L., Ivanivska, T., Sidorenko, S.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: cell surface receptors; chemosensitivity.; chemotherapeutic drugs; chronic lymphocytic leukemia B cells; ex vivo
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-1-4
• Journal Title: Experimental Oncology

Summary. Response of chronic lymphocytic leukemia (CLL) patients to classical chemoimmunotherapy that remains the main strategy in treatment of this disease is strikingly variable. This issue requires the finding of biomarkers which could predict efficiency of drug administration and choose the best...