Aggregated proteins in malignant and benign neoplasms

• Date: 2023
• Main Authors: Zabolotnyi, D.I., Belousova, A.A., Zabolotna, D.D., Savchenko, T.D., Voroshylova, N.M., Timchenko, M.D., Tsvirinko, I.R., Verevka, S.V.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: benign neoplasms; keloids; malignant tumors; polyposis; protein aggregation
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2019-1-3
• Journal Title: Experimental Oncology

Summary. Aim: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. Results: The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. Conclusion: The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology.