ОВАРІАЛЬНА ТОКСИЧНІСТЬ FAC-СХЕМИ ХІМІОТЕРАПІЇ В ЕКСПЕРИМЕНТІ ТА МОЖЛИВОСТІ ЇЇ КОРЕКЦІЇ ПЛАЗМОЮ, ЗБАГАЧЕНОЮ ТРОМБОЦИТАМИ

• Date: 2023
• Main Authors: Shamrai, V.A., Misiurko, O.I., Grebeniuk, D.I., Taran, I.V.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: FAC-схема хіміотерапії; оваріальна токсичність; плазма; збагачена тромбоцитами; антимюллерів гормон; естрадіол; фолікулостимулювальний гормон
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2022-3-11
• Journal Title: Experimental Oncology

Aim: To compare the dynamics of changes in the hormonal status of female rats in the setting of the FAC (5-fluorouracil, doxorubicin and cyclophosphamide) chemotherapy and after local administration of platelet-rich plasma (PRP). Materials and Methods: The study was carried out on female Wistar rats treated according to the FAC chemotherapy scheme (4 courses with a 3-week interval). The ovariotoxic effect of the FAC chemotherapy was assessed by the levels of anti-Mullerian hormone, estradiol (E2) and follicle-stimulating hormone in the proestrus phase. Three weeks after the last course of chemotherapy, 5 rats were administered with local intra- and periovarian injection of PRP (triply with a 1-week interval). Results: The dynamics of all investigated hormonal markers of the ovarian reserve in experimental animals was characterized by a progressive decrease in anti-Mullerian hormone and E2 levels and an increase in follicle-stimulating hormone level. The dynamics of the studied parameters after the serial administration of PRP demonstrated an improvement in the hormonal status. Conclusion: FAC chemotherapy in the experiment causes premature ovarian failure, and local administration of PRP improves the hormonal parameters of the ovarian reserve.