Препаративний метод синтезу 4-(трифлуорометокси)піперидину та 4-(трифлуорометоксиметил)піперидину

• Date: 2021
• Main Authors: Logvinenko, Ivan G., Dolovanyuk, Violetta G., Kondratov, Ivan S.
• Format: Article
• Language: Ukrainian
• Published: National University of Pharmacy 2021
• Subjects: флуорування; трифлуорометоксигрупа; ксантат; піперидин; захисна група
• Online Access: https://ophcj.nuph.edu.ua/article/view/222669
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 4-(trifluoromethoxy)-piperidine and 4-(trifluoromethoxymethyl)piperidine – promising building blocks for medicinal chemistry.Results and discussion. 4-(Trifluoromethoxy)piperidine (8.4 g) and 4-(trifluoromethoxy...